Acylation of myelin Po protein is required for adhesion

2000 ◽  
Vol 60 (6) ◽  
pp. 704-713 ◽  
Author(s):  
Ying Gao ◽  
Wenhui Li ◽  
Marie T. Filbin
Keyword(s):  
Po Protein

A 42 K protein of chick sciatic nerve is immunologically related to PO protein of peripheral nerve myelin

1987 ◽  
Vol 12 (4) ◽  
pp. 377-384 ◽  
Author(s):  
David J. Nunn ◽  
Andr�a C. LeBlanc ◽  
Catherine Mezei
Keyword(s):  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Po Protein

The Role of Myelin Po Protein

1997 ◽  
pp. 103-114
Author(s):  
Marie T. Filbin ◽  
Man Har Wong ◽  
Kejia Zhang ◽  
Wen Hui Li
Keyword(s):  
Po Protein

scholarly journals Anti-Cancer Effects of Protein Extracts fromCalvatia lilacina,Pleurotus ostreatusandVolvariella volvacea

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Jin-Yi Wu ◽  
Chi-Hung Chen ◽  
Wen-Huei Chang ◽  
King-Thom Chung ◽  
Yi-Wen Liu ◽  
...  
Keyword(s):  
Cell Line ◽  
Colorectal Adenocarcinoma ◽  
Leukemia Cell Line ◽  
Dependent Manner ◽  
Ros Production ◽  
Monocytic Leukemia ◽  
Anti Cancer ◽  
Sw480 Cells ◽  
Po Protein ◽  
Human Monocytic Leukemia

Calvatia lilacina(CL),Pleurotus ostreatus(PO) andVolvariella volvacea(VV) are widely distributed worldwide and commonly eaten as mushrooms. In this study, cell viabilities were evaluated for a human colorectal adenocarcinoma cell line (SW480 cells) and a human monocytic leukemia cell line (THP-1 cells). Apoptotic mechanisms induced by the protein extracts of PO and VV were evaluated for SW480 cells. The viabilities of THP-1 and SW480 cells decreased in a concentration-dependent manner after 24 h of treatment with the protein extracts of CL, PO or VV. Apoptosis analysis revealed that the percentage of SW480 cells in the SubG1phase (a marker of apoptosis) was increased upon PO and VV protein-extract treatments, indicating that oligonucleosomal DNA fragmentation existed concomitantly with cellular death. The PO and VV protein extracts induced reactive oxygen species (ROS) production, glutathione (GSH) depletion and mitochondrial transmembrane potential (ΔΨm) loss in SW480 cells. Pretreatment withN-acetylcysteine, GSH or cyclosporine A partially prevented the apoptosis induced by PO protein extracts, but not that induced by VV extracts, in SW480 cells. The protein extracts of CL, PO and VV exhibited therapeutic efficacy against human colorectal adenocarcinoma cells and human monocytic leukemia cells. The PO protein extracts induced apoptosis in SW480 cells partially through ROS production, GSH depletion and mitochondrial dysfunction. Therefore, the protein extracts of these mushrooms could be considered an important source of new anti-cancer drugs.

scholarly journals Complete amino acid sequence of PO protein in bovine peripheral nerve myelin.

1987 ◽  
Vol 262 (9) ◽  
pp. 4208-4214
Author(s):  
Y. Sakamoto ◽  
K. Kitamura ◽  
K. Yoshimura ◽  
T. Nishijima ◽  
K. Uyemura
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Peripheral Nerve ◽  
Complete Amino Acid Sequence ◽  
Po Protein

Po protein in normal, trembler heterozygous/homozygous mice during active PNS myelination

Neuroreport ◽  
1992 ◽  
Vol 3 (7) ◽  
pp. 594-596 ◽  
Author(s):  
Bertrand Garbay ◽  
Jacques Bonnet
Keyword(s):  
Po Protein

Mapping the adhesive domains of the myelin Po protein

1996 ◽  
Vol 45 (5) ◽  
pp. 525-533 ◽  
Author(s):  
K. Zhang ◽  
Y. Merazga ◽  
M.T. Filbin
Keyword(s):  
Po Protein
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